CircRNA: A New Bridge Between Gynecological Drug-Resistant Pathogens and Gene Regulation

Abstract

The emergence of antibiotic-resistant strains, a consequence of the misuse of antibiotics, has rendered drug-resistant bacterial infections an increasingly critical issue in the realm of gynecological infectious diseases. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have been identified as potential stable regulators of gene expression. Evidence suggests that circRNAs can modulate the immune milieu by influencing macrophage polarization and inflammatory pathways, potentially offering a novel therapeutic strategy against drug-resistant infections. This review outlines prevalent drug-resistant pathogens in gynecology and explores the potential and mechanisms by which circRNAs could mitigate gynecological inflammations unresponsive to antibiotic treatments, laying the groundwork for future investigative endeavors.